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INTRODUCTION Neonatal bacterial sepsis, exacerbated by neonatal immunodeficiency (), remains a major cause of mortality and morbidity in newborns (). Vancomycin is widely used for the treatment of late-onset sepsis caused by methicillin-resistant Staphylococcus aureus and coagulase-negative staphylococci in neonatal intensive care units (NICUs) (); however, the clinical use of vancomycin is still hampered by its narrow therapeutic index and high pharmacokinetic variability (). Indeed, de Hoog et al. Reported that vancomycin clearance and half-life varied between 0.63 and 1. Edius 6 05 Usb Dongle Crack Forums. 4 ml/kg/min and between 3.5 and 10 h in neonates, respectively (). The common adverse effects of vancomycin are nephrotoxicity and ototoxicity; however, it has been shown that neonates tolerated vancomycin better than adults. Safety data for a high dosing regimen and long-term follow-up are still lacking.

The pharmacokinetic modeling approach is often applied to evaluate and optimize antimicrobial therapy in neonates (). To date, vancomycin is one of the best-studied antimicrobials, and numerous studies have been conducted to characterize its pharmacokinetic parameters and to identify individual factors influencing variability (). However, the clinical application of model-based personalized vancomycin therapy is still limited. The objective of the present study was to evaluate the clinical utility and safety of a patient-tailored dose of vancomycin in neonates. Model-based patient-tailored dose of vancomycin.Special training was conducted in each NICU. Scribblenauts Unlimited Free No Download.